Rhinovirus infections

Rhinovirus infections P . G . HIGGINS

The rhinoviruses were the most recently described agents to be sought in the MRC/PHLS studies. Not until 1960 was a practical routine method for their detection described (Tyrrell & Parsons, 1960) with the result that, at the commencement of the studies in October 1964, few reports were available based on a substantial number of isolates. However, rhinoviruses had been shown to be associated wi...

Mechanism of human rhinovirus infections

About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein receptor family, some ICAM-1, and some use CDHR3 for host cell infection. This is also reflected in the pathways exploited for cellular entry. We found that even rhinovirus serotypes binding the ...

Association of rhinovirus infections with asthma.

Rhinoviruses are the most common cause of the common cold, but they can cause more severe illnesses in people with underlying lung disorders such as asthma, chronic obstructive pulmonary disease, or cystic fibrosis. Epidemiologic studies with sensitive detection methods such as PCR have identified rhinovirus infection as a major source of asthma exacerbations in both children and adults, especi...

Role of rhinovirus infections in asthma.

Human rhinoviruses are not only the main pathogens responsible for the common cold, but are now recognized to have a major impact on asthma pathogenesis. There is evidence that rhinovirus infections play a role in asthma development, asthma exacerbations and, potentially, airway remodeling. Children who experience repeated rhinovirus-induced wheezing episodes in infancy have a significantly inc...

New aspects on human rhinovirus infections.